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Home » Keytruda Approved as First-Line Treatment for Colorectal Cancer
Keytruda Approved as First-Line Treatment for Colorectal Cancer
July 1, 2020
The FDA has approved Merck’s blockbuster cancer drug Keytruda (pembrolizumab) as a first-line immunotherapy for certain patients with colorectal cancer.
The patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) tumors account for approximately 5 percent of patients with metastatic colorectal cancer. The MSI-H and dMMR tumors contain abnormalities that affect the proper repair of DNA inside the cell.
The approval was based on trial results showing that patients treated with Keytruda demonstrated a progression-free survival of 16.5 months compared to 8.2 months for those who received chemotherapy.
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