Home » Kosan Presents Data on Motilin Agonists to Treat Gastrointestinal Disorders
Kosan Presents Data on Motilin Agonists to Treat Gastrointestinal Disorders
May 18, 2005
Kosan Biosciences has presented preclinical data describing the properties of novel erythromycin-based motilin agonists, motilides, for stimulating gastrointestinal motility.
Erythromycin is an effective treatment for gastroparesis; however, some of its properties, including antibiotic activity, are not appropriate for a drug designed for chronic use over a patient's lifetime. Earlier efforts to produce erythromycin analogs with reduced antibiotic activity resulted in compounds that lost efficacy in repeated dosing regimens (tachyphylaxis).
These compounds also blocked in vitro the hERG channel in the heart, a finding associated with an increased risk for dangerous arrhythmias, or irregular heart rhythms.
KEYWORDS Drug Pipeline Alert
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