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BIOPURE'S MARKETING APPLICATION FOR HEMOPURE ACCEPTED FOR REVIEW IN UNITED KINGDOM

September 12, 2006

Biopure Corporation announced that the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) has validated the marketing authorization application (MAA) the company submitted on July 10, 2006 for Hemopure [hemoglobin glutamer -- 250 (bovine)] for the treatment of acutely anemic adult orthopedic surgery patients under 80 years of age. Validation signifies that the application is complete and has been accepted for review.

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