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TRIPOS COMPLETES BUY OF OPTIVE RESEARCH

January 6, 2005

Tripos has completed its acquisition of Optive Research, an Austin, Texas, firm that develops, markets and supports life science software, the company said. The purchase price included $4.75 million in cash and 599,521 shares of Tripos stock, which closed at $5.31 a share Tuesday. Based on that price, the stock portion of the purchase would be nearly $3.2 million.

St. Louis Business Journal (http://www.bizjournals.com/stlouis/stories/2005/01/03/daily39.html)