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Cardiome Pharma Announces Closing of Underwriters' Over-Allotment Option

March 31, 2005

Cardiome Pharma Corp. announced that the underwriters of its recently completed public offering have exercised their over-allotment option in full, purchasing an additional 1,275,000 common shares for gross proceeds of approximately US$7.6 million. All of the over-allotment shares were sold by the company. The combined gross proceeds to the company of the public offering and the exercise of the over-allotment option totaled approximately US$58.6 million.

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