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AstraZeneca has signed a collaboration deal with Scorpion Therapeutics to discover, develop and commercialize precision medicines against previously hard-to-target cancer proteins, the so-called “undruggable” targets. Read More
Sanofi has agreed to buy exclusive global rights to develop Korean company ABL Bio’s preclinical antibody for the treatment of neurodegenerative conditions, including Parkinson’s disease. Purchase price: $75 million upfront, with additional payments that could total $1 billion. Read More
Amgen and Arrakis Therapeutics have teamed up to develop targeted RNA degraders, an entirely new class of therapeutic molecules designed to destroy disease-causing RNA. Read More
Results seen across multiple trials bolster Sarepta’s “confidence in the potential disease-modifying benefits of this therapy,” said the company’s CEO, Doug Ingram. Read More
BioMarin plans to meet with the FDA to discuss these latest findings and expects to file a biologics license application in the second quarter of this year. Read More
Bayer and Mammoth Biosciences have announced a deal in which Bayer will shell out $40 million now and potentially up to $1 billion over time for the use of Mammoth’s CRISPR systems to develop in vivo gene-editing therapies. Read More
After flopping a phase 3 trial in hospitalized COVID-19 patients, Molecular Partners’ antiviral ensovibep has scored in a new phase 2 study, reducing viral load and cutting the risk of hospitalization or death by 78 percent in patients with mild-to-moderate disease. Read More
Tirzepatide, Eli Lilly’s potential dual-molecule blockbuster for type 2 diabetes (T2D), should be priced at $5,500 to $7,500 per year to be a cost-effective therapeutic option, according to the Institute for Clinical and Economic Review (ICER). Read More
Single-dose protection was 63 percent; by 13 days after boosting, it had risen to 84 percent, where it hovered for up to two months after the booster. Read More
The study did return positive results in overall quality of life and some hints of survival benefit at 12 months, so BridgeBio isn’t throwing the molecule in the dustbin yet. Read More
CoronaVac, Sinovac’s COVID-19 vaccine, appears to be completely ineffective against the Omicron variant unless boosted with an mRNA vaccine, new data suggest. Read More